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WhatsApp: +86 18221755073The mixed lineage leukaemia (MLL) family of proteins (including MLL1–MLL4, SET1A and SET1B) specifically methylate histone 3 Lys4, and have pivotal roles in the transcriptional regulation of ...
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WhatsApp: +86 18221755073While the human KMT2 family was initially named the mixed lineage leukemia (MLL) family, due to the role of the founding member KMT2A (also called MLL, MLL1, ALL-1, HRX) in this disease, recent exome-sequencing studies revealed KMT2 genes to be among the most frequently mutated genes in many types of human cancers. Efforts to integrate the ...
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WhatsApp: +86 18221755073（mixed lineage leukemia,MLL）1123（11q23）,Ziemin-van der Poel 1991。 MLL,、 。 MLL、（PTD）、、 ...
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WhatsApp: +86 18221755073The MLL Leukemia. Human leukemias with an MLL translocation account for >50% of acute lymphoblastic leukemia (ALL) in infants less than 6 mon of age and for up to 10% of both de novo acute lymphoblastic and acute myeloid leukemia (AML) in children and adults. 14 Furthermore, MLL translocations are also observed in ∼33% of therapy …
WhatsApp: +86 18221755073Like other methyltransferases, MLL is a part of large nuclear complexes that include many different proteins of varied function 28,29,30.Although not extensively studied, current evidence suggests ...
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